Yes, with a USB-to-RS232 converter. Performance of these converters and their software drivers may vary widely based on the manufacturer. Acromag has qualified the Edgeport/1 USB-RS232 converter (p/n 301-1001-11) as compatible with the components of the IntelliPack Software Interface Package (800C-SIP). Compatibility was verified with Microsoft Windows 98, ME, 2000, & XP operating systems. Windows NT4 does not support USB and was not tested. The IntelliPack Configuration software tested was 9500-124K version. The Edgeport driver tested was 2.0 version. Edgeport products may be found at www.ionetworks.com. Lastly, other USB converters and drivers may also work but have not been tested.